About this historical patient account: The information below describes reported observations from one case. It does not establish treatment efficacy, safety, a causal relationship or an expected outcome. Outcomes vary, and reported improvement does not demonstrate cure. Do not change prescribed medicines or delay established care based on this account.

Intervention context: This account does not establish that the cell, growth-factor or other biological interventions described are approved or effective for this diagnosis. Some may be investigational. A qualified specialist should explain the current evidence, regulatory status, alternatives, uncertainties and risks before any treatment decision.

Patient Information:

• Name: Judy Maureen Kusel
• Diagnosis: Breast Cancer (HER2-positive infiltrating ductal carcinoma)
• Date of Birth (D.O.B): November 21, 1946
• Gender: Female
• Country: Canada

Treatment: Comprehensive Treatment at Beijing Puhua International Hospital for Metastatic Breast Cancer, including:

• Sono-dynamic therapy
• DC-CIK cell therapy
• Traditional Chinese Medicine (TCM)

Medical History before Admission:

69-year-old female patient, Ms. Judy Maureen Kusel:

• Underwent right breast lumpectomy in January 2004 followed by chemotherapy and radiation for HER2-positive infiltrating ductal carcinoma.
• In April 2013, she underwent a right breast mastectomy with extensive skin grafting, Photodynamic Therapy, and surgical removal of lymph nodes.
• Received radiation therapy to her right thorax internal mammary lymph-node chain in January 2015.
• PET-CT scan in May 2015 indicated recurrent FDG soft tissue lesions within the right chest wall and left breast. Stereotactic radiation was administered for these lesions in June 2015.

Treatment Details at Beijing Puhua International Hospital:

Sono-dynamic therapy:

• Two procedures performed on July 24, 2015 targeting two subcutaneous lesions (0.5cm and 0.3cm) in the right chest wall.
• Patient tolerated procedures well with no reported complications.

DC-CIK cell therapy:

• Infusion delivered on August 3, 2015

Traditional Chinese Medicine (TCM):

• Acupuncture and herbal therapy to enhance energy levels and improve overall condition

Medical Condition after Treatment:

Upon discharge, Ms. Kusel's physical condition showed significant improvement with no discomfort experienced throughout her treatment. Post-treatment scans are recommended for optimal response evaluation.

Patient Testimonial:
Mr. & Mrs. Kusel expressed high satisfaction with the cancer treatment program at Beijing Puhua International Hospital and shared their positive experience through a video testimonial. The follow-up team at BPIH will continue to monitor Ms. Kusel's progress post-discharge.

About this historical patient account: The information below describes reported observations from one case. It does not establish treatment efficacy, safety, a causal relationship or an expected outcome. Outcomes vary, and reported improvement does not demonstrate cure. Do not change prescribed medicines or delay established care based on this account.

Intervention context: This account does not establish that the cell, growth-factor or other biological interventions described are approved or effective for this diagnosis. Some may be investigational. A qualified specialist should explain the current evidence, regulatory status, alternatives, uncertainties and risks before any treatment decision.

Patient Information:

• Name: Guido Rico Agreda
• Diagnosis: Metastatic Adenocarcinoma of Colon
• Date of Birth (D.O.B): August 31, 1942
• Gender: Male
• Country: Bolivia

Treatment: Comprehensive Treatment at Beijing Puhua International Hospital for Metastatic Adenocarcinoma of Colon, including:

• Radio-Frequency Ablation (RFA)
• Systemic Chemotherapy (Capecitabine)
• Cytokine-Induced Killer Cells (CIK Cell) Therapy
• Traditional Chinese Medicine (TCM)

Medical History before Admission:

73-year-old male patient, Mr. Guido Rico Agreda:

• Underwent right semi-colectomy in 2006 for moderately-differentiated adenocarcinoma of the colon with positive lymph node involvement (+1/20), Dukes C.
• Completed adjuvant chemotherapy (12 cycles of 5-FU and LV civ48hs)
• Experienced progressive enlargement of peritoneal lymph nodes, necessitating excision in 20XX
• Undergone Radio-Frequency Ablation (RFA) for liver metastases

Treatment Details at Beijing Puhua International Hospital:

Radio-Frequency Ablation (RFA):

• Two procedures performed on September 15 and 29, 20XX respectively.
• Each procedure involved ablating two liver lesions using multi-electrode needles heated to 90°C for varying durations (10-15 minutes).
• Local injections of interleukin-2 (1,000,000 IU) and GM-CSF (150 µg) were administered post-procedure.
• Patient tolerated procedures well with no complications.

Systemic Chemotherapy:

• Capecitabine 825-1000mg/m² Bid, D1-14

Immunotherapy & Traditional Chinese Medicine (TCM):

• Cytokine-Induced Killer Cells (CIK cells) therapy administered twice during admission
• Acupuncture and Chinese herbal therapy as supportive interventions described in the report; reduced toxicity or treatment benefit is not established by this case

Medical Condition after Treatment:

Upon discharge, Mr. Agreda's physical condition showed continued improvement with no discomfort experienced throughout his treatment. The historical account reports an estimate of tumor necrosis after RFA. The assessment method and longer-term outcome are not provided here, so the claim should not be treated as a quantified treatment benefit or expected response. Optimal response evaluation via repeat CT or PET-CT scan recommended around one month post-treatment.

Post-Operative:

Mr. and Mrs. Agreda expressed high satisfaction with the cancer treatment and services provided at Beijing Puhua International Hospital. Mr. Agreda willingly shared his treatment experiences to benefit prospective patients.

About this historical patient account: The information below describes reported observations from one case. It does not establish treatment efficacy, safety, a causal relationship or an expected outcome. Outcomes vary, and reported improvement does not demonstrate cure. Do not change prescribed medicines or delay established care based on this account.

Patient Information:

• Name: EL Hadj
• Diagnosis: Metastatic Liver Cancer (with Hepatitis B history)
• Date of Birth (D.O.B): December 31, 1968
• Gender: Male
• Country: Mauritania

Treatment: PD-1 Immunotherapy combined with Traditional Chinese Medicine (TCM) at Beijing Puhua International Hospital

Medical Condition before Anti-Cancer Treatment for Liver Cancer:

EL Hadj is a 47-year-old male who presented with:

• Abdominal pain for the past 9 months
• Lower limb edema for the past 2 months
• Hepatitis B history for the past 4 years
• Widespread metastatic liver cancer diagnosed 9 months ago
• Metastasis to the right femoral neck with pathological fracture of the right femur (treated with nail internal fixation)
• Abdominal distension (abdominal circumference: 84 cm), weak bowel sounds, and dullness upon percussion throughout the body
• Tenderness and pressing pain in the right upper abdomen; liver's inferior margin palpable 10 cm below the xiphoid process
• A fist-sized mass detected in the midline of the right upper abdomen
• Persistent abdominal pain despite taking analgesics (Acesodyne)

Medical Condition after Anti-Cancer Treatment for Liver Cancer:

Following a 2-week course of PD-1 immunotherapy combined with Traditional Chinese Medicine, EL Hadj's general condition showed significant improvement:

• Appetite improved notably
• Abdominal pain significantly reduced compared to his pre-treatment state