Patient Information:

• Name: José Silva
• Diagnosis: Ataxia due to Paraneoplastic Subacute Cerebellar Degeneration related to Limited-Stage Small Cell Lung Cancer
• Date of Birth (D.O.B): June 12, 1956
• Gender: Male
• Country: Portugal

Medical History:

• Treated HCV infection
• Pulmonary tuberculosis diagnosed histologically in 1998 by left upper lobectomy due to suspected neoplasia
• Toxic hepatitis
• Limited-stage small cell lung cancer diagnosed in August 2014, with concurrent chemo-radiotherapy treatment; no evidence of recurrence to date

Treatment: Stereotactic Brain Procedure Surgery combined with Nerve Growth Factor Transplantation, Traditional Chinese Medicine (TCM), and Physical Therapy at Beijing Puhua International Hospital (BPIH)

Medical Condition before Treatment:

• Rapid onset severe cerebellar ataxia
• Imbalance and dysarthria

Treatment Course:
After admission to BPIH, José completed relevant examinations, and the following medical protocols were applied:

• Stereotactic brain procedure surgery
• Nerve growth factor transplantation
• Traditional Chinese Medicine (TCM)
• Rehabilitation therapy

The entire treatment course lasted for two weeks.

Medical Condition after Treatment:
Immediately following the stereotactic brain procedure surgery combined with nerve growth factor transplantation:

• Neurological Examination Improvements:
  • Significant improvement in finger-to-nose test and alternating movement test
  • Improved balance, as reported by José's daughter

Post-Treatment Outlook:
Further changes would require follow-up assessment and cannot be predicted from this account. BPIH will continue to monitor his progress closely.

Patient Information:

• Name: Omar
• Diagnosis: Hereditary Cerebellar Ataxia
• Date of Birth (D.O.B): February 2, 1979
• Gender: Male
• Country: Egypt

Treatment: Neural Growth Factor Therapy, supplemented with cerebral blood circulation improvement and nutritional therapy

Medical History:
Omar, a 35-year-old male, was admitted to Beijing Puhua International Hospital in June 2014. He reported decreased vision for the previous eight years and unsteady gait with slurred speech for the past three years. He was diagnosed with hereditary cerebellar ataxia.

Medical Condition before Treatment:

• Unable to stand independently due to impaired balance and motility
• Dysarthria (slurred speech)
• Decreased vision

Treatment Course:
Omar underwent Neural Growth Factor Therapy, combined with additional treatments focusing on improving cerebral blood circulation and nutrition. This was supplemented with Traditional Chinese Medicine (TCM) and rehabilitation training.

Post-Treatment Updates:
Upon discharge, Omar demonstrated significant improvements in:

• Vision
• Hand rotation movements
• Finger-nose test stability
• Balance maintenance on balance plate training (reduced falling incidents)
• Single leg balance performance with minimal assistance
• Bilateral heel-knee-tibia test stability
• Gait improvement; able to walk independently

Post-Discharge Outlook:
Further changes would require follow-up assessment and cannot be predicted from this account.

Patient Information:

• Name: Mouayad I.A. Khalafalla
• Diagnosis: Hereditary Ataxia
• Date of Birth (D.O.B): May 8, 1986
• Gender: Male
• Country: Sudan

Treatment: Nerve Growth Factor Treatment, Cerebral Metabolism Improving Treatment, Neurotrophic Treatment, Traditional Chinese Medicine (TCM), and Rehabilitation Therapy

Medical History:
Mouayad was admitted to Puhua International Hospital on May 31st, 2011, presenting with a 10-year history of unsteady walking. He was diagnosed with hereditary ataxia.

Medical Condition before Nerve Growth Factor Treatment for Hereditary Ataxia:
Post-admission examinations revealed:

• Cerebellar atrophy and scoliosis
• Poor balance; tendency to fall while walking
• Backward body inclination during gait
• Difficulty climbing stairs without handrail support
• Limited self-control during squat testing
• Clumsy coordinated movements and alternating motions
• Weak muscle strength
• Pronounced fatigue during exercise

Treatment Course:
Mouayad underwent Nerve Growth Factor Treatment, focusing on cerebral metabolism improvement and neurotrophic effects. This was complemented by Traditional Chinese Medicine (TCM) and comprehensive rehabilitation therapy.

Post-Treatment Updates:
Following Nerve Growth Factor Treatment for Hereditary Ataxia:

• Significantly improved condition upon discharge
• Improved gait: No falls; better performance in rehabilitation training, including squatting, ball tossing, coordinated movements, and alternating motions
• Normalized body habitus during walking; able to climb stairs without handrail support
• Enhanced finger flexibility, as reported by his parents with multiple examples
• Tour of the Great Wall (50 steps climbed without undue fatigue)
• Long walk at Tiananmen Square on the day before discharge, feeling much improved compared to pre-treatment condition

Patient Information:

• Name: Kreem I.A. Khalafalla
• Diagnosis: Hereditary Ataxia
• Date of Birth (D.O.B): June 29, 1989
• Gender: Male
• Country: Sudan

Treatment: Neural Growth Factor Therapy for Hereditary Ataxia, Cerebral Metabolism Improvement Treatment, Neurotrophic Treatment, Traditional Chinese Medicine (TCM), and Rehabilitation Therapy

Medical History:
Kreem was admitted to Puhua International Hospital on May 31st, 2011, presenting with unsteady walking that had progressed over seven years. He was diagnosed with hereditary ataxia.

Medical Condition before Neural Growth Factor Treatment for Hereditary Ataxia:
At admission:

• Gait: Difficult to walk even with assistance; often lost balance and fell
• Fatigue: Easily fatigued
• Limb coordination: Poor, especially in the legs; clumsy alternating movements

Treatment Course:
Kreem underwent Neural Growth Factor Therapy targeting cerebral metabolism improvement and neurotrophic effects. This was combined with Traditional Chinese Medicine (TCM) and comprehensive rehabilitation therapy.

Post-Treatment Updates:
Following Neural Growth Factor Treatment for Hereditary Ataxia:

• Gait: Improved steadiness while standing and walking; better balance control
• Endurance: Able to walk longer distances with reduced fatigue
• Historical trip: During his hospitalization, Kreem visited the Great Wall of China and Tiananmen Square, climbing the wall and enjoying a long walk without significant fatigue
• Physical examination: Upon discharge, Kreem's fingers showed increased flexibility compared to his condition upon admission

Patient & Family Feedback:
Kreem and his parents were highly satisfied with the results of his Neural Growth Factor Therapy. They expressed optimism regarding further improvements in Kreem's condition after discharge from Puhua Hospital.