Stem Cell Therapy for Traumatic Brain Injury (TBI) with Tetraplegia

Patient Profile

• Name: Omar Jose Alana Fernandez
• Diagnosis: Brain trauma and tetraplegia
• Date of Birth: August 31, 1975
• Gender: Male
• Country: Venezuela

Treatment:

• Neural stem cell injections via lumbar puncture combined with:
  • Self-stem cell activation and proliferation program
  • Rehabilitation therapy
  • Traditional Chinese Medicine (TCM)

Medical History

Omar Fernandez, a 35-year-old male from Venezuela, was admitted to Puhua International Hospital (PIH) in Beijing due to "Motion disorder in four limbs and aphasia following a traffic accident and subsequent surgery." He suffered a severe brain trauma after a road traffic accident on March 23, 2000. The accident resulted in mixed aphasia, spastic hemiplegia on the right side of his body, spastic hemiparesis on the left side, quadriparesis, motor aphasia, and dependence on a stoma feeding fistula for nourishment.

Medical Condition Before Stem Cell Treatment (SCT)

• Confined to a wheelchair with no independent mobility
• Head drooping; unable to support body properly
• Muscle strength: Legs 0/5
• Relatively clear consciousness despite motor aphasia

Stem Cell Treatment (SCT)

Omar underwent neural stem cell injections via lumbar puncture, followed by a self-stem cell activation and proliferation program. Additionally, he received rehabilitation therapy and Traditional Chinese Medicine (TCM) treatments.

Medical Condition After Stem Cell Treatment (SCT)

After completing his SCT, Omar experienced substantial improvements:

• Regained the ability to swallow liquid food independently, allowing him to discontinue the stoma feeding fistula
• Improved head control; able to hold up his head unassisted for short periods and maintain a straighter body posture
• Increased trunk strength and stability
• Improved muscle strength in legs:
  • Left leg: 2/5 (able to move independently)
  • Right leg: 1/5 (improved movement control)

This account reports changes in daily function after several interventions. It cannot establish that stem cell therapy caused those changes or predict results for other patients.

Stem Cell Therapy for Cerebral Hemorrhage

Patient Profile

• Name: Weizhong Wang
• Diagnosis: Cerebral hemorrhage
• Date of Birth: July 31, 1956
• Gender: Male
• Country: China

Treatment:

• Stem cell injections combined with:
  • Self-stem cell activation and proliferation program
  • Rehabilitation training

Medical History

Mr. Wang was admitted to Puhua International Hospital on November 16, 2020, eight months after suffering a cerebral hemorrhage that had left him in a vegetative state despite surgical intervention. He was discharged on December 13, 2020.

Medical Condition Before Stem Cell Treatment (SCT)

Prior to SCT, Mr. Wang's medical condition was as follows:

• Poor general condition with impaired mobility
• Limited functionality; could only open and close his eyes

Stem Cell Treatment (SCT) for Cerebral Hemorrhage

During his hospitalization, Mr. Wang underwent a multidisciplinary treatment approach including:

• Stem cell injections described in this historical report; neural repair and regeneration are not established by this case
• A programme described historically as self-stem cell activation and proliferation; the claimed regenerative effect is not established by this case
• Rehabilitation training focused on improving motor function and overall recovery

Medical Condition After Stem Cell Treatment (SCT)

Four weeks following SCT for cerebral hemorrhage, Mr. Wang exhibited notable improvements in his medical condition:

• Increased responsiveness; became more aware of his surroundings compared to his admission state
• Improved muscle tone in all four limbs
• Clearer breath sounds
• Muscle strength temporarily increased in the upper limbs upon receiving cold-stimulus in the sacral region

Stem Cell Therapy for Traumatic Brain Injury (TBI)

Patient Profile

• Name: Albert James De Meillon
• Diagnosis: Sequelae of traumatic brain injury (TBI)
• Date of Birth: March 31, 1956
• Gender: Male
• Country: South Africa

Treatment:

• Stem cell therapy combined with:
  • Microcirculation and neuronal nutrition improvement strategies
  • Traditional Chinese Medicine (TCM)
  • Rehabilitation therapy

Medical History

Albert was admitted to Puhua International Hospital (PIH) on June 27, 2011, for stem cell treatment (SCT), following a traumatic brain injury sustained in a car accident several years prior. The injury had resulted in speech, walking, and memory impairments.

Medical Condition Before Stem Cell Treatment (SCT)

Prior to SCT, Albert's condition was characterized by the following symptoms:

• Slurred speech with word repetition and difficulties forming complex sentences
• Impaired concentration, orientation, imagination, and learning abilities
• Clumsy movements, particularly on his left side
• Wide-based gait due to instability while walking

Stem Cell Treatment (SCT) for TBI

Albert underwent a multidisciplinary treatment approach, including:

• Stem cell administration described in this historical report; neural repair and regeneration are not established by this case
• Therapies aimed at improving microcirculation and neuronal nutrition
• Traditional Chinese Medicine (TCM) to support overall recovery
• Rehabilitation therapy focused on motor function, balance, and cognitive improvement

Medical Condition After Stem Cell Treatment (SCT)

Following SCT, Albert demonstrated noticeable improvements in his speech, gait, memory, movements, and learning abilities:

• Clearer articulation with improved pronunciation of previously challenging words
• Longer sentences and better descriptions with reduced repetition during conversations
• Steadier gait with enhanced balance control and the ability to walk along a straight line
• Improved short-term memory and faster learning capabilities
• Richer imagination and better time and place orientation

Stereotactic Surgery for Brain Injury

Patient Profile

• Name: Stanley Padley
• Diagnosis: Traumatic Brain Injury (TBI) following surgery
• Date of Birth: January 5, 1959
• Gender: Male
• Country: United Kingdom

Treatment:

• Stereotactic Surgery combined with:
  • Neural function improvement therapy
  • Cerebral blood circulation and metabolism promotion
  • Traditional Chinese Medicine (TCM)
  • Rehabilitation therapy

Medical History

Mr. Stanley Padley, a 57-year-old male, sustained a brain injury following an operation in 2009. Magnetic Resonance Imaging (MRI) revealed softening lesions in both hemispheres of his brain, accompanied by cerebral atrophy. The injury left him unable to speak or eat due to the loss of sensation in his tongue. A percutaneous endoscopic gastrostomy (PEG) tube was inserted for feeding purposes.

Stanley experienced difficulties walking and relied on an electronic wheelchair for daily activities. He was admitted to Beijing Puhua International Hospital in April 2015 due to speech and mobility disorders that had persisted for over six years.

Medical Condition Prior to Stereotactic Surgery

Before the intervention, Stanley's condition was as follows:

• Speech: Unable to protrude or move his tongue; unable to speak
• Mobility: Difficulties moving due to increased muscle tension in lower limbs, particularly the right lower limb. Right elbow joint was in a slight extended-contracture position.
• Muscle Strength:
  • Left upper limb: 5-/5
  • Right upper limb (proximal): 4/5
  • Left lower limb: 4/5
  • Right lower limb: 4-/5

Stereotactic Surgery for Sequela of Brain Injury

Upon admission, Stanley underwent a comprehensive treatment program that included:

• Neural function improvement therapy to enhance recovery of brain functions
• Promotion of cerebral blood circulation and metabolism to facilitate healing and plasticity
• Traditional Chinese Medicine (TCM) to complement Western medical treatments
• Rehabilitation therapy to regain motor skills, balance, and coordination

Medical Condition after Stereotactic Surgery

Upon completion of the treatment program, Stanley's general condition improved significantly:

• Swallowing Function: Improved; able to consume banana slurry and other semi-liquid diets
• Tongue Sensation: Reported having some feeling in his tongue
• Mobility: Increased flexibility in limbs
• Muscle Strength:
  • Left upper limb: 5-/5
  • Right upper limb (proximal): 5-/5
  • Left lower limb: 5-/5
  • Right lower limb: 4/5

Follow-up

The historical one-year follow-up after stereotactic surgery reported the following changes in mobility:

• Able to walk much better than before without any supports
• Enjoys activities such as playing football and bowling independently

Stanley's family is delighted with his progress and remains optimistic about his continued recovery and improved quality of life.

Image captions:

1. MRI image showing bilateral softening lesions and cerebral atrophy prior to surgery.
2. Photograph of Mr. Stanley Padley demonstrating his improved mobility one year after Stereotactic Surgery.